A runaway second half from the Titans has ended Manly's tournament with a 24-4 victory and booked a semi-final meeting against the Warriors.

After making the quarter-final stage for the first time, the Titans have progressed a step furthern and set up a tough challenge against the Warriors who wilkl be spurred on by a vocal big crowd.

But the Titans, sprinkled with five NRL debutants and some hardened topliners, have been undoubtedly the tournament giant-kille after losing their first match to the Sharks.

Manly and Gold Coast traded line breaks early through Matt Parcell, Tom Trbojevic and Anthony Don but neither team was able to capitalise from their early chances.

A beautiful kick behind the line by Tom Trbojevic from 35 metres out earned a drop out and from there Trbojevic slotted into a right side shift and produced a deft catch and pass to put Brayden Wiliame over for first points in the right corner.

Manly coach Trent Barrett's heart would have skipped a beat shortly after when Trbojevic's ankle twisted under him in a tackle forcing him from the field for assessment, with Manly's 18-man squad already down to 13 fit players.

Shortly after a relentless passage of offloads from the Titans resulted in Nene McDonald crossing next to the posts for a 6-4 lead at half-time.

Trbojevic was back to start the second half and immediately returned to causing the Gold Coast defence headaches, but it was a length-of-the-field David Mead try that stretched the Titans' lead to 13-4.

A rampaging 50-metre solo try from Chris McQueen, his third of the tournament, put the result beyond doubt then a brilliant Nathan Davis offload set up a leaping Anthony Don just inside the corner post to make it a 24-4 final score.

Gold Coast Titans 24 (McDonald, Mead, McQueen, Don tries; Roberts, Bird, Paasi goals) def. Manly Sea Eagles 4(Wiliame try).